The Academics
Glenn Howerton as Dr. Jack Griffin
A.P. Bio may be very a lot designed as a showcase for TV comedy heavy hitter Glenn Howerton. Previous to (and certainly concurrently with and after) his function as Jack Griffin, Howerton was finest recognized for portraying Dennis Reynolds on long-running FX comedy It’s At all times Sunny in Philadelphia. Occurring twenty years, Howerton’s performances because the borderline sociopathic Dennis has been a comedic masterclass. Now viewers have gotten to know him a bit higher by way of The At all times Sunny Podcast and his award-winning function as Blackberry co-founder Jim Balsillie in 2023’s Blackberry.
Lyric Lewis as Stef Duncan
Stef Duncan is a historical past trainer at Whitlock Excessive College and a part of the unshakeable Stef-Mary-Michelle friendship trio. Taking part in her is Lyric Lewis, who has beforehand appeared in TV comedies Baskets, iCarly, and Social gathering Down.
Mary Sohn as Mary Wagner
Mary is an artwork trainer at Whitlock Excessive College and a part of the aforementioned Stef-Mary-Michelle friendship trio. Taking part in her is Mary Sohn, a comedic actress who has appeared in Miracle Employees, Between Two Ferns: The Movie, and Curb Your Enthusiasm. She has additionally made a number of appearances voicing characters on the Comedy Bang! Bang! podcast.
Jean Villepique as Michelle Jones
Michelle Jones is the house economics trainer at Whitlock Excessive College and is the oddball spoke of the Stef-Mary-Michelle friendship trio. Jean Villepique has popped up in quite a few comedy collection since 2007, together with The Workplace, Fashionable Household, and Veep. Shortly earlier than A.P. Bio, she voiced adoption caseworker Tracy in BoJack Horseman.
Patton Oswalt as Principal Ralph Durbin
Principal Ralph Durbin is the overmatched chief of Whitlock Excessive College and the closest factor Jack Griffin has to a “buddy.” Taking part in Durbin is the prolific comedy legend Patton Oswalt, who has been in … simply, every little thing. Along with his long-running profession as a standup comedian and actor, Oswalt is understood to younger audiences because the voice of Remy in Pixar’s Ratatouille.
Paula Pell as Helen Henry Demarcus
The peerlessly-named Helen Henry Demarcus is Principal Durbin’s secretary who views him as one thing resembling her husband, son, finest buddy, and platonic soulmate. Taking part in Helen is comedic secret weapon Paula Pell. A revered author at Saturday Night time Stay from 1995 by way of 2020, Pell has moved in entrance of the digicam extra lately, taking part in outstanding roles in Parks and Recreation, Documentary Now!, and Girls5eva.
