The explosion turned what should have been the happiest night of their lives into a scene of unimaginable devastation.
The couple had been asleep after celebrating their wedding when the blast ripped through the home at around 7.00am on Sunday.
Six other people – including family members and wedding guests who had stayed overnight – also lost their lives.
More than a dozen others were injured.
The powerful explosion caused the roof to collapse and blew sections of the walls away.
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When rescue teams arrived, they were met with piles of bricks, shattered furniture and massive slabs of concrete strewn across the floor.
Several injured victims were trapped beneath the rubble and had to be pulled out on stretchers as emergency workers raced against the clock.
Officials said the blast was caused by a gas leak that filled the room before igniting.
The force of the explosion was so strong that it damaged three neighbouring houses, leaving residents in shock.
The chairman of Pakistan’s Senate, Yusuf Raza Gilani, described the tragedy as “a heart-wrenching incident that turned celebrations into mourning”.
Hanif Masih, the groom’s father, said his son had been married just the day before.
The newlyweds, along with relatives and guests, had all gone to sleep inside the house following the wedding festivities.
Masih said everyone went to bed around 3.00am, only to wake up to scenes of chaos hours later.
Along with his son, Masih said his daughter-in-law, wife and sister-in-law were all killed in the blast.
Police said the area was immediately cordoned off as investigations began into the circumstances surrounding the explosion.
Forensic officers wearing white protective suits were deployed to carefully sift through the debris.
Deputy police commissioner Sahibzada Yousaf told local media that sniffer dogs and advanced technology were used to ensure no one remained trapped beneath the rubble.
Liquefied petroleum gas cylinders are commonly used in households across Pakistan for cooking and fuel.
Unfortunately faulty equipment and leaks have been linked to a series of deadly accidents in the past.
Gilani said the incident raised serious concerns and stressed that more needed to be done to prevent similar tragedies occurring.
“Such incidents demand that relevant departments fulfil their responsibilities seriously and ensure safety measures,” he said in a statement.